Prepared for a front-row seat to the subsequent scientific revolution?
That’s the concept behind Doudna — a groundbreaking supercomputer introduced in the present day at Lawrence Berkeley Nationwide Laboratory in Berkeley, California. The system represents a significant nationwide funding in advancing U.S. high-performance computing (HPC) management, guaranteeing U.S. researchers have entry to cutting-edge instruments to handle world challenges.
“It’ll advance scientific discovery from chemistry to physics to biology and all powered by — unleashing this energy — of synthetic intelligence,” U.S. Power Secretary Chris Wright (pictured above) stated at in the present day’s occasion.
Often known as NERSC-10, Doudna is known as for Nobel laureate and CRISPR pioneer Jennifer Doudna. The following-generation system introduced in the present day is designed not only for velocity however for impression.
Powered by Dell Applied sciences infrastructure with the NVIDIA Vera Rubin structure, and set to launch in 2026, Doudna is tailor-made for real-time discovery throughout the U.S. Division of Power’s most pressing scientific missions. It’s poised to catapult American researchers to the forefront of essential scientific breakthroughs, fostering innovation and securing the nation’s aggressive edge in key technological fields.
“I’m so proud that America continues to speculate on this explicit space,” stated NVIDIA founder and CEO Jensen Huang. “It’s the basis of scientific discovery for our nation. It’s also the inspiration for financial and know-how management.”
“It’s an unimaginable honor to be right here,” Doudna stated, including she was “shocked and delighted” {that a} supercomputer can be named after her. “I believe we’re standing at a very fascinating second in biology,” she added, with folks with completely different expertise coming collectively to handle world points.
Designed to Speed up Breakthroughs
Not like conventional programs that function in silos, Doudna merges simulation, information and AI right into a single seamless platform.
“The Doudna supercomputer is designed to speed up a broad set of scientific workflows,” stated NERSC Director Sudip Dosanjh. “Doudna will likely be linked to DOE experimental and observational amenities by means of the Power Sciences Community (ESnet), permitting scientists to stream information seamlessly into the system from all components of the nation and to investigate it in close to actual time.”
It’s engineered to empower over 11,000 researchers with virtually instantaneous responsiveness and built-in workflows, serving to scientists discover greater questions and attain solutions sooner than ever.
“We’re not simply constructing a sooner pc,” stated Nick Wright, superior applied sciences group lead and Doudna chief architect at NERSC. “We’re constructing a system that helps researchers assume greater and uncover sooner.”
Right here’s what Wright expects Doudna to advance:
- Fusion power: Breakthroughs in simulation that unlocks clear fusion power.
- Supplies science: AI fashions that design new courses of superconducting supplies.
- Drug discovery acceleration: Ultrarapid workflow that helps biologists fold proteins quick sufficient to outpace a pandemic.
- Astronomy: Actual-time processing of knowledge from the Darkish Power Spectroscopic Instrument at Kitt Peak to assist scientists map the universe.
Doudna is anticipated to outperform its predecessor, Perlmutter, by greater than 10x in scientific output, all whereas utilizing simply 2-3x the facility.
This interprets to a 3-5x enhance in efficiency per watt, a results of improvements in chip design, dynamic load balancing and system-level efficiencies.
AI-Powered Discovery at Scale
Doudna will energy AI-driven breakthroughs throughout high-impact scientific fields nationwide. Highlights embody:
- AI for protein design: David Baker, a 2024 Nobel laureate, used NERSC programs to help his work utilizing AI to foretell novel protein constructions, addressing challenges throughout scientific disciplines.
- AI for basic physics: Researchers like Benjamin Nachman are utilizing AI to “unfold” detector distortions in particle physics information and analyze proton information from electron-proton colliders.
- AI for supplies science: A collaboration together with Berkeley Lab and Meta created “Open Molecules 2025,” an enormous dataset for utilizing AI to precisely mannequin advanced molecular chemical reactions. Researchers concerned additionally use NERSC for his or her AI fashions.
Actual-Time Science, Actual-World Impression
Doudna isn’t a standalone system. It’s an integral a part of scientific workflows. DOE’s ESnet will stream information from telescopes, detectors and genome sequencers immediately into the machine with low-latency, high-throughput NVIDIA Quantum-X800 InfiniBand networking.
This essential information movement is prioritized by clever quality-of-service mechanisms, guaranteeing it stays quick and uninterrupted, from enter to perception.
This may make the system extremely responsive. On the DIII-D nationwide fusion ignition facility, for instance, information will stream control-room occasions immediately into Doudna for rapid-response plasma modeling, so scientists could make changes in actual time.
“We used to consider the supercomputer as a passive participant within the nook,” Wright stated. “Now it’s a part of the whole workflow, linked to experiments, telescopes, detectors.”
The Platform for What’s Subsequent: Unlocking Quantum and HPC Workflows
Doudna helps conventional HPC, cutting-edge AI, real-time streaming and even quantum workflows.

This contains help for scalable quantum algorithm growth and the codesign of future built-in quantum-HPC programs, utilizing platforms like NVIDIA CUDA-Q.
All of those workflows will run on the next-generation NVIDIA Vera Rubin platform, which can mix high-performance CPUs with coherent GPUs, that means all processors can entry and share information on to help essentially the most demanding scientific workloads.
Researchers are already porting full pipelines utilizing frameworks like PyTorch, the NVIDIA Holoscan software program growth equipment, TensorFlow, NVIDIA cuDNN and NVIDIA CUDA-Q, all optimized for the system’s Rubin GPUs and NVIDIA NVLink structure.
Over 20 analysis groups are already porting full workflows to Doudna by means of the NERSC Science Acceleration Program, tackling the whole lot from local weather fashions to particle physics. This isn’t nearly uncooked compute, it’s about discovery, built-in from concept to perception.
Designed for Urgency
Final yr, AI-assisted science earned two Nobel Prizes. From local weather analysis to pandemic response, the subsequent breakthroughs gained’t anticipate higher infrastructure.
With deployment slated for 2026, Doudna is positioned to steer a brand new period of accelerated science. DOE amenities throughout the nation, from Fermilab to the Joint Genome Institute, will depend on its capabilities to show in the present day’s questions into tomorrow’s breakthroughs.
“This isn’t a system for one subject,” Wright stated. “It’s for discovery — throughout chemistry, physics and fields we haven’t imagined but.”
As Huang put it, Doudna is “a time machine for science.” It compresses years of discovery into days and provides the world’s hardest issues the facility they’ve been ready for.
This submit has been up to date with feedback from Thursday’s occasion at Lawrence Berkeley Nationwide Laboratory.